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The μ-opioid receptor (MOP) is a subtype that belongs to the superfamily of 7-transmembranespanning G-protein-coupled receptors. Pharmacological studies with gene-knockout mice show that MOP is a major target for the clinically important opioid drugs, such as morphine and fentanyl, and it appears to play critical roles in the mediation of the major effects of these opioid drugs, including analg...

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During the Irish famine of 1846-1851 there were an estimated 1.0 million excess deaths, the migration of 1.3 million persons, and 300,000 averted births. To assess the influence of population changes at the local level in Ulster, decennial census records were analyzed for the Barony of Upper Ards, County Down, from 1841 to 1911. Data on marriages contracted in the four Roman Catholic, five Pres...

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followed by a stepwise progression to stronger centrally acting analgesics [5] . Analgesics can be broadly categorized as: non-opioid, opioid and adjuvant analgesics. Non-opioids may be used in combination with opioids for their opioid-sparing effect, permitting the use of lower doses of opioids [6] . Opioids are primarily used to treat moderate to severe pain that has not responded to non-opio...

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